骨桥蛋白在原发性肝癌中的表达及其与预后的关系

THE expression and prognostic significanct of osteopontin in primary hepatocellular carcinoma

目的探讨骨桥蛋白(OPN)在原发性肝癌中的表达及其与临床、病理、预后之间的关系。方法采用免疫组化SP法检测32例原发性肝癌组织、4例正常肝脏组织中OPN的表达,分析其表达与肝癌及肝癌患者预后的关系。结果①原发性肝癌组织中OPN表达明显高于正常组织(P<0.01)。②OPN的阴性表达与阳性表达在肿瘤的分级中存在差异(P<0.05),而与患者的性别、年龄、肿瘤直径、AFP水平无关(P>0.05)。③OPN阳性表达生存期相对缩短,为一负性预后因子。结论OPN阳性表达与肝癌的发生;

Objective To investigate the expression and prognostic significance of osteopontin in primary hepatocellular carcinoma （HCC） .Methods The expression of OPN in 42 primary HCC and 4 normal liver was detected using SP Immunohistochemieal technique. Results （1）OPN expression was mainly in the cytoplasm d cell,the positive rate of OPN in HCC cell was higher than that in mmnal liver cell（P 〈 0.01. （2）OPN positivity was remarkably correlated with the invasion and metastasis（P 〈 0.05）.（3）OPN is the passitie factor in the prognosis of HCC. Conclusion OPN expression was higher in HCC and its significantly related to the prognosis of HCC.