萘哌地尔联合舍尼亭治疗女性膀胱过度活动症的疗效观察

Naftopidil combined with Tolterodine Tartrate in the treatment of female overactive bladder

目的探讨萘哌地尔联合舍尼亭治疗女性膀胱过度活动症的疗效。方法对31例诊断为女性膀胱过度活动症的患者行萘哌地尔加舍尼亭治疗。以自由尿流率的主要参数如最大尿流率(Qmax)、平均尿流率(Qave)、排尿量(VV)和尿道综合征症状评分(FUSS)、生活质量评分(QOL)为主要疗效指标,来观察治疗效果。结果治疗前后的尿流率参数值(Qmax、Qave、VV)、FUSS、QOL相比较,差异显著(P<0.05),总有效率为83.88%。结论萘哌地尔加舍尼亭联合应用可作为女性膀胱过度活动症的一种有效治疗手段。

Objective To evaluate naftopidil and tolterodine tartrate in the reatment of patients with female overactive bladder （OAB）. Methods Thirty-one female patients suffering from overactive bladder were treated with naftopidil tablet and tolterodine tartrate for 4 weeks. The effects were evaluated mainly with urodynamic data, including maximum flow rate （Qmax）, average flow rate（Qave）, voiding volume（VV）, female urethral syndrome score （FUSS） and quality of life （QOL）. Results Urodynamic data （Qmax, Qave,VV） increased, while FUSS decreased significantly after 4 weeks＇ treatment. There was statistically significant difference of urodynamics data, FUSSY＇and QOL before and after treatment （P〈0.01 or P〈0.05）. The total effective rate was 83.88%. Conclusion Naftopidil and tolterodine tartrate could be an effective therapeutic method for patients with OAB.