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妊娠相关血浆蛋白A对妊娠滋养细胞疾病诊断及预后价值的探讨 被引量：2

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摘要 目的探讨妊娠相关血浆蛋白A(PAPP-A)对妊娠滋养细胞疾病(GTD)的诊断及预后价值。方法2002-2005对西安交通大学第一医院25例正常孕妇、28例完全性葡萄胎及38例侵蚀性葡萄胎采用酶联免疫吸附法(ELISA)检测治疗前、治疗中以及随访过程中的血清PAPP-A,同时检测血清β-HCG水平。结果葡萄胎组及侵蚀性葡萄胎组血清β-HCG水平均高于对照组(P<0.05),但葡萄胎组与侵蚀性葡萄胎组间β-HCG差异无统计学意义(P>0.05)。葡萄胎组血清PAPP-A显著高于对照组(P<0.05),侵蚀性葡萄胎组血清PAPP-A显著高于对照组及葡萄胎组(P<0.05)。葡萄胎恶性转归组血清β-HCG和PAPP-A均明显高于良性转归组(P<0.05)。β-HCG水平与侵蚀性葡萄胎临床分期无关,而PAPP-A与临床分期呈正相关。良性葡萄胎清宫术后β-HCG和PAPP-A均呈下降趋势,恶变时β-HCG和PAPP-A略有升高或持续阳性。结论PAPP-A检测可能早期诊断良、恶性葡萄胎,并有助于早期预测葡萄胎恶变。
作者 方静 苟文丽
机构地区 西安交通大学第一医院妇产科
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2007年第2期129-130,共2页 Chinese Journal of Practical Gynecology and Obstetrics
关键词 妊娠相关血浆蛋白A Β-人绒毛膜促性腺激素 葡萄胎 侵蚀葡萄胎
分类号 R71 [医药卫生—妇产科学]
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参考文献6

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中国实用妇科与产科杂志
2007年 第2期

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