不同强度低氧训练对NK CELL活性的损害效应研究

Study on the Harmful Effect of Hypoxic Training of Different Intensity on Nature Killer Cell Activity

目的:研究不同强度低氧训练后大鼠脾NK细胞活性的变化,探讨不同强度、不同低氧训练方式对机体免疫功能的影响。方法:120只大鼠按照氧环境(常氧、高住低练、低氧)和训练强度(无、中和高强度)随机形成9种组合,中等强度训练5周,高强度训练6周,乳酸脱氢酶释放法测定NK活性。结果:训练强度、氧环境与训练强度的交互作用对NK细胞活性具有显著影响;常氧高强度训练能显著提高NK细胞活性,低氧和高住低练高强度训练对NK活性无促进作用;常氧、低氧环境下中等强度训练对NK活性无显著影响,但高住低练环境下中等强度训练会严重损害NK细胞功能。结论:低氧和高住低练环境下高强度训练不利于NK活性的提高;高住低练环境下长期中等强度训练会严重降低NK细胞功能。

Objective： Nature killer （NK） cell activities in spleen of rats after hypoxie training of different intensity were studied in order to inquire into the immunity function of body. Methods：120 rats were randomly divided into 9 combinations according to the oxygen environment [normal o2, living high and training low（HiLo）, living low and training low（LL）]and the training intensity [no training, middle intensity training（MT）and high intensity training（HT ）]. The period of training was 5 wks （MT） and 6 wks （HT） respectively. Nature killer cell activities in spleen were measured by means of lactic dehydrogenized releasing. Results： The NK activity were significantly influenced by the intensity of training and the intersect effect of the O2 environment and training intensity. HT in normal oxygen could improve the NK activity remarkable, but HT of LL and HiLO could not.The NK activity were not significantly changed after the MT in normal o2 and LL, but it was remarkably decreased after MT of HiLO. Conclusion： HT of LL and HiLO has unfavorable effect on NK activity. Long period MT of HiLo could damage the function of NK seriously.