摘要
Parkinson＇s disease is a neurodegenerative disorder mainly caused by degeneration of the dopaminergic neurons in the substantia nigral pars compacta （SNpc）. The typical motor symptoms of this disease are tremor, akinesia, and rigidity, which are mostly caused by dysfunction of the nigro-striatal pathway. Dopaminergic neurons in the SNpc project long axons to caudate nucleus and the putamen, and secrete dopamine.
Parkinson＇s disease is a neurodegenerative disorder mainly caused by degeneration of the dopaminergic neurons in the substantia nigral pars compacta （SNpc）. The typical motor symptoms of this disease are tremor, akinesia, and rigidity, which are mostly caused by dysfunction of the nigro-striatal pathway. Dopaminergic neurons in the SNpc project long axons to caudate nucleus and the putamen, and secrete dopamine.
基金
grants from the Science and Technology Commission of Shanghai Municipality(No.03D214021 and No.04DZ14902)
the E-Institutes of Shanghai Municipal Education Commission(No.iE03003).
