黄独的化学成分

Chemical constituents of Dioscorea bulbifera L.

目的研究中药黄独(Dioscorea bulbifera L.)乙醇提取物的乙酸乙酯萃取部分的化学成分。方法采用硅胶、Sephadex LH-20柱色谱等方法进行分离,利用理化性质和1H-NMR13C-NMR等谱学技术,对分离得到的化合物进行结构鉴定。结果从中分离得到6个化合物,其结构鉴定为(+)儿茶素(catechin,1)、3,5-二甲氧基山柰酚(3,5-dimethoxykaempferol,2)、山核桃素(caryatin,3)、山柰酚(kaempferol,4)、山柰酚-3-O-β-D-吡喃半乳糖苷(kaempferol-3-O-β-D-galactopyranoside,5)、山柰酚-3-O-β-D-吡喃葡萄糖苷(kaempferol-3-O-β-D-glucopyranoside,6)。结论化合物4、6为首次从薯蓣属植物中分离得到的已知化合物。

Objective To isolate and identify the compounds from the EtOAc fraction of 75% EtOH extract of Dioscorea bulbifera L. Methods Compounds were isolated by the silica gel and Sephadex LH-20 columns, and their structures were identified by the physicochemical characters especially by the spectral analysis. Results Six compounds were obtained and they were identified as （ ＋ ）catechin （1）, 3, 5-dimethoxykaempferol （2）, caryatin （3）, kaempferol （4）, kaempferol-3-O-β-D-galactopyranoside （5）, kaempferol-3-O-β-D-glucopyranoside （6）. Conclusions Compounds 4 and 6 were obtained from Dioscorea genus for the first time.