对比增强超声对猪肝轻度损伤的初步研究

Contrast-enhanced ultrasound for mild hepatic trauma in pigs: preliminary evaluation

目的应用对比增强超声来探索肝割裂伤口的位置、范围及图像特征。方法两只巴马小型猪,用手术刀经皮经肝作深20mm,宽10mm的切口。静脉注入超声造影剂(SonoVue)来显示伤口的位置、范围和图像特点。结果经皮经肝形成的割裂口,于裂口的位置用二维声像图(基波和谐波模式)上无法显示伤口的位置和范围。注入造影剂后,肝实质高回声消退后,呈线状强回声的割裂口显示十分清晰,此处的强回声一直持续时间较长。另外,紧贴裂口处的肝包膜下,可见线状强回声。肝实质内造影剂完全消除后,将造影模式转换成灰阶模式,仍见裂口处的强回声条索,并见其后方的弱声影。再反转成彩色血流成像模式,于裂口处彩色血流明显增强。结论由于造影剂的原因,割裂口在对比增强超声图上显示为强回声。因此,对比增强超声能反映肝脏损伤的程度和损伤区的部位、形态和范围。

Objective To evaluate position of trauma and characterization with contrast-enhanced ultrasound （CEUS）. Methods A defined mild intraparenchymal lesion was in 2 pigs. Ultrasound （baseline ultrasound, CDFI, CEUS） was performed after trauma with a contrast agent （SonoVue）. Ultrasound features were observed. Results In 2 pigs, focal intraparenchymal lesions of liver with diameters ranging from 20.0 to 10.0 mm were found that could be identified using CDFI and CEUS. Focal intraparenchymal lesions of liver could not be detected with the basehne ultrasound. Hyperechoic rift in liver was visible along trauma area as enhancement in hepatic parenchyma disappeared on CEUS. Hyperechoic line could be kept in a long time. Sub-capsular region beside a traumatic lesion also appeared hyperechoic rift. Hyperechoic rift in traumatic region could be still kept as a result from CEUS to conventional B-mode ultrasound. Enhancement in traumatic lesion was clearly seen in CDFL Conclusion Hyperechoic rift in liver is visible along trauma area as a result of a contrast agent. CEUS have is potentially useful in the judging grade, field and position of hepatic injury.