穿琥宁溶液的稳定性研究

Study on the Stability of Potassium Dehydroandrographolide Succinate Solution in Different Conditions

目的研究穿琥宁溶液在不同条件下的稳定性。方法采用经典恒温法考察了穿琥宁在不同pH值的磷酸盐缓冲液,相同pH值的不同缓冲盐溶液及不同浓度的枸橼酸盐缓冲液中的稳定性。结果穿琥宁在pH6.5时最为稳定;枸橼酸盐缓冲液能延缓其水解;枸橼酸盐的浓度不影响药物稳定性。结论穿琥宁溶液在不同条件下稳定性不同,该结果为穿琥宁的分析及相关制剂的研究提供了参考。

Objective To study the stability of potassium dehydroandrographolide sueeinate solution in different eonditions. Methods The elassieal thermostatie test was adopted to investigate the stability of potassium dehydroandrographolide sueeinate in phosphate buffer solutions of different pH values, in different buffer solutions of the same pH value and in eitrate buffer solutions of different eoneentrations. Results The stability of potassium dehydroandrographolide succinate solution was different at different pH values and was the best at pH 6. 5. In various buffer solutions of pH 6.5, the hydrolyzation of potassium dehydroandrographolide sueeinate solution was delayed by eitrate buffer solution, and the stability of the solution had no eorrelation with the eoneentration of eitrate buffer solution. Conclusion The stability of potassium dehydroandrographolide sueeinate solution varies in different eonditions. This will supply a referenee for the study on potassium dehydroandrographolide sueeinate solution and its similar preparations.