缺氧诱导因子-1α与动脉粥样硬化易损斑块

Hypoxia-inducible Factor-1α and Vulnerable Plaque of Atherosclerosis

缺氧诱导因子-1是一种分布和作用都很广泛的细胞转录因子,是唯一特异性缺氧条件下发挥活性的因子。缺氧诱导因子-1α是缺氧诱导因子-1的氧调节亚单位,决定了缺氧诱导因子-1的活性。研究表明缺氧诱导因子-1α参与了动脉粥样硬化的发生发展,与易损斑块有密切的关系。

Hypoxia-inducible factor-1 （ HIF-1 ） is a transcription factor,with extensive distribution and functions in cells,and is the only specific factor in hypoxia. Hypoxia-inducible factor-1 α is the oxygen modulation subunit of HIF-1 ,which determines the activity of HIF-1. Much research suggests that HIF-1 α is involved in the genesis and development of atherosclerosis,and is closely related to vulnerable plaque.