摘要
异构前列腺素是自由基催化,花生四烯酸的过氧化产物,在细胞膜上被磷脂酶释放,在血浆中循环,最后从尿排出。其化学性质稳定是过氧化反应特异的产物,是评价氧化应激和脂质过氧化反应最有效的生物指标。它激活血小板,收缩血管,促进血管平滑肌有丝分裂并引起心肌细胞肥大,在临床心力衰竭的病理生理发展中起了重要作用。TP受体拮抗剂、抗氧化剂及活性氧簇抑制剂能显著减少异构前列腺素的合成及延缓心力衰竭的进展。
Isoprostanes are formed by free radical-catalyzed peroxidation of arachidonic acid. They are released by phospholipase in cellular membrane,circulate in plasma,ultimum and are excreted in urine. Isoprostanes are a specific and chemically stable product of peroxiclarion,so they are the best biological index used to estimate oxidative stress and peroxidation. Isoprostanes can activate platelets, contract blood vessels,promote vascular smooth muscle to caryocinesis and evoke cardiocyte to hypertrophy. They have important effects on the pathophysiology of clinical heart failure. TP receptor antagonist, antioxidant, and ROS catastahica can significantly reduce synthesis of isoprostanes, and delay the progress of heart failure.
出处
《心血管病学进展》
CAS
2007年第2期276-279,共4页
Advances in Cardiovascular Diseases
