肾移植受者血清sCD30水平与移植后急性排斥反应发生的关系

Relationship between Acute Rejection in Kidney Transplantation and Expression of sCD30

目的探讨肾移植前后血清中sCD30水平与移植术后急性排斥反应的关系。方法利用ELISA试剂盒检测62例肾移植受者移植前、移植后3,7,21 d血清中sCD30的水平。结果肾功能衰竭患者移植前血清sCD30水平比正常人高(P<0.0001);移植后发生急性排斥的受者移植前血清sCD30水平较未发生急性排斥者高(P=0.01);术后第3,7 d sCD30的水平与急性排斥反应的发生有明显的相关性(P<0.01),而未发生排斥反应的患者sCD30则很快下降。术后第21 d肾移植受者的sCD30水平基本已降至正常水平,与正常对照组比较无统计学意义(P>0.05)。结论提示肾移植前及移植后7 d内测定sCD30水平有助于预测术后发生急性排斥的风险。

Objective Investigating the relationship of pre-and-post-transplant serum content of sCD30 for kidney transplantation recipients and acute rejection. Methods Pre-and post-transplant serum content of sCD30 for 62 cases with kidney transplantation recipients was tested using a commercially available enzyme-linked immunosorbent assay （ELISA）kit. Results Pre-transplant serum sCD30 concentration in the recipients with renal failure was significantly higher than health control （P〈0. 0001）;pretransplant serum sCD30 concentration in the recipients with acute rejection was higher than ones without acute rejection （P=0. 01）;On post-transplant day 3 and day 7 serum sCD30 indicated impending graft rejection（P 〈0.01） ,while the serum content of sCD30 in patients without acute rejection decrea,sed rapidly. Day 21 serum sCD30 concentration in the recipients wasn＇t shown obviously different from health control. Conclusion These data show that serum sCD30 concentrartion of pre-transplanlt and post-transplant within day 7 may predict the risk of acute rejection for kidney transplant.