外周血出现有核红细胞患者网织红参数与乳酸脱氢酶分析的意义

The Significance of Reticulocyte Parameter and Lactic Acid Dehydrogenase Analysis in NRBCs Positive Patients

目的观察外周血出现有核红细胞(NRBC)患者网织红细胞参数与乳酸脱氢酶(LDH)水平的改变情况及其临床意义。方法应用XE-2100全自动血细胞分析仪检测住院病人抗凝全血标本,对NRBC计数阳性的58例病例,检测标本中网织红参数,同时应用Roche-Module D2400全自动生化分析仪,检测该病人血清中LDH水平。并将144例外周血未检出NRBC的住院病人设为对照组。结果外周血检出NRBC 58例患者分布于18个不同科室。外周血检出NRBC患者与外周血未检出NRBC病人网织红百分率(RET%)、高荧光强度网织红百分率(HLR%)、中荧光强度网织红百分率(MLR%)、LDH水平均有显著性差异(P<0.001)。结论外周血出现NRBC患者RET%,HLR%,MLR%和LDH水平明显升高,结合网织红参数和LDH水平有助于对外周血出现NRBC患者的病因诊断和预后评价。

Objective To observe reticulocyte parameter and lactic acid dehydrogenase of the nucleated red blood cells （NRBCs） positive patients and to discuss changes and its clinical significances. Methods Using a sysmex XE-2100 analyzer examines the inpatient antlcoagulation whole blood specimen, to the NRBC-positlve patients （n= 58） specimen detect its reticulocyte parameters,and using a Roche-Module D2400 analyzer detect that patient＇s serum lactic acid dehydrogenase at the same time. Results 58 cases of NRBC-positive patients distribute in 18 different division of the hospital. The reticulocyte percentage （RET % ）, high scattered light intensity reticulocyte percentage （HLR % ）, middle scattered light intensity reticulocyte percentage （MLR%）and lactic acid dehydrogenase of NRBC-positive patients were significantly higher （P〈0. 001） than NRBC-negative patients. Conclusion The RET%, HLR%,MLR% and LDH of NRBC-positive patients would be significantly higher than NRBC-negative patients. Combining reticulocyte parameter and lactic acid dehydrogenase may help NRBC-positive patients etiological diagnosis and prognostic evaluation.