手性衍生化试剂MTPEA酰胺衍生物的合成

Synthesis of the Amide Derivatives of Chiral Derivatizing Agent MTPEA

本文报导了争性衍生化试剂ＭＴＰＥＡ酰胺衍生物的合成方法．Ｄ，Ｌ－２－甲氧基－２－三氟甲基－２－本基乙胺（ＭＴＰＥＡ）与十个光学活性羧酸在二环已基碳二亚胺（ＤＣＣ）的存在下直接反应；分别生成等量的非对映异构酰胺．通过ＩＲ、￣１ＨＮＭＲ、￣１３ＣＮＭＲ、ＭＳ及元素分析等方法测定了各酰肤的结构．此外，还讨论了酰胺分子在质谱中的裂解方式．

The synthetic method of the amide derivatives of chiral derivatizing agent MTPEA is described. Ten eqUimolar diastereomeric amides were prepared separately by the direct reactions of D, L -2-methoxy-2-trifluoromethyl-2-phenylethylamine(MTPEA) with ten optically active carboxylic acids in the presence of N, N'-dicyclohexyl-carbodiimide(DCC). The structures of all products were determined by methods of IR; 1H NMR; 13C NMR; MS and 'elemental analysis. And the fragmentation pathways of the amides in Mass spectrometry(EI+) were discussed.