田基黄的化学成分研究

Studies on Chemical Constituents of Hypericum japonicum

目的研究田基黄(Hypericum japonicum Thunb.)的化学成分。方法运用多种色谱技术对田基黄的化学成分进行系统研究,根据光谱数据鉴定化合物结构。结果分离鉴定了12个化合物,分别为:异巴西红厚壳素(Ⅰ),槲皮素(Ⅱ),山柰酚(Ⅲ),槲皮素-7-O-α-L-鼠李糖苷(Ⅳ),槲皮苷(Ⅴ),异槲皮苷(Ⅵ),槲皮素-3-O-β-D-葡萄糖醛酸苷(Ⅶ),田基黄双酮(Ⅷ),3,8″-biapigenin(Ⅸ),白桦酸(Ⅹ),豆甾醇(Ⅺ),豆甾醇-3-O-β-D-葡萄糖苷(Ⅻ)。结论化合物Ⅶ,Ⅸ,Ⅻ为首次从该植物中分离得到。

OBJECTIVE To investigate the chemical constituents of Hypericum japonicum. METHODS The compounds were separated by chromatography and their chemical structures were elucidated by means of MS, ^1 H-NMR and ^13C-NMR spectral methods, respectively. RESULTS Twelve compounds were isolated from the plant,they were identified as isojacareubin （ Ⅰ ） ,quercetin （ Ⅱ ）, kaempferol （ Ⅲ ）, quercetin-7-O-α-L-rhamnoside （ Ⅳ ）, quercitrin （ quercetin-3-O-α-L-rhamnoside, Ⅴ ）, isoquercitrin （ quercetin-3-O- β-D-glucoside, Ⅵ ）, miguelianin （ quercetin-3-O-β-D-glucuronide,Ⅶ ）, bijaponicaxanthone （ Ⅷ）, 3,8＂-biapigenin （ Ⅸ ）, betulinic acid （Ⅹ） ,stigmasterol （Ⅺ） and stigmasterul-3-O-β-D-glucopyranoiside （Ⅻ）. CONCLUSION Compound Ⅶ, Ⅸ and Ⅻ are isolated from this plant for the first time.