滋生青阳片改善高血压左室肥厚中医证候及降压的临床研究

Clinical study of Zisheng Qingyang Tablet for improving left ventricle hypertrophy of essential hypertension's traditional Chinese medicine syndromes and lowering blood pressure

目的:探讨滋生青阳片改善高血压左室肥厚(LVH)患者的中医证候的疗效及降压作用。方法:60例辨证为阴虚阳亢、心气亏虚的高血压LVH病人随机分为治疗组(滋生青阳片)和对照组(卡托普利片),每组30例,疗程4个月。于治疗前后分别给中医证候作半定量计分,测血压。结果:治疗组与对照组均能明显减少中医证候积分,但证候积分及证候疗效治疗组明显优于对照组(P<0.01,P<0.05),其差异尤其体现在减轻眩晕、头痛、胸闷、心悸等主要症状方面,两组均能明显降低血压(P<0.01),但两组之间无明显差异(P>0.05)。结论:滋生青阳片能较好改善阴虚阳亢、心气亏虚型高血压LVH病人中医证候及其疗效,尤其体现在减轻眩晕、头痛、胸闷、心悸等主要症状方面,明显优于卡托普利片。滋生青阳片与卡托普利片的降压作用相当。

AIM： To explore the action of Zisheng Qingyang Tablet for improving left ventricle hypertrophy of essential hyertension＇s traditional Chinese medicine syndromes and for lowering blood pressure（BP）. METHODS： There were 60 patients, whose syndrome differentiation typing（SDT） was the yin-deficiency and yang-hyperactivity, the deficiency of heart-qi with dizziness caused by wind accompanied cardiac hypertrophy （essential hypertension left ventricle hypertrophy）. The 60 patients were randomly divided into treating group and comtrol group each group with 30 patients. 4 months was one course of treatment. Pre-and post-therapy, the total scores of each group, the individual syndrome＇s scores of each group and the levels of BP were marked. RESULTS： After treating, the TCM syndromes of two groups were relieved. The total scores and improvements of TCM syndromes were markedly higher than that of the control group, and the significance especially displays on relieving main symptoms, such as dizziness, headache, chest distention and palpitation（P 〈 0.01 ）. the levels of blood pressure in treatment group and control group descen markedly （ P 〈 0.05 ）, the two groups had no difference in lowering BP （ P 〉 0.05 ）. CONCLUSION： Zisheng Qingyang Table can obviously improve TCM syndromes, The effects especially exist in relieving the main symptoms as follows： dizziness, headache, chest distention, palpitation. The action of Zisheng Qingyang Tablet and captopril for lowering BP is alike.