摘要
目的了解急性脑出血患者血清胰岛素样生长因子-1(IGF-1)水平的动态变化及其临床意义。方法采用放免法测定40例脑出血患者起病后2天内、2周时血清IGF-1的含量,并与20例健康者对照比较。结果发病2天内脑出血患者血清IGF-1水平明显低于对照组,相比较有显著差异(P<0.01),2周时血清IGF-1水平有恢复。结论脑出血患者急性期血清IGF-1浓度明显降低,脑出血患者急性期血清IGF-1水平可帮助判断病情轻重和预后。IGF-1也许能通过血脑屏障产生神经保护,具有潜在的临床价值。
Objective To investigate the dynamic changes of serum insulin - like growth factor - 1 （ IGF - 1 ） levels in patients with acute cerebralhemorrhage. Methods Serum levels were determined with RIA in 40 patients with cerebralhemorrhage within 2 days and at 14 days and 20 healthy individuals serve as control groups. Results The serum IGF - 1 levels in patients with cerebralhemorrhage were significantly lower than those in controls （P 〈 0.01 ） ,at 14 days,levels of serum IGF - 1 rose somewhat. Conclusions Serum levels of IGF - 1 dropped markedly during the acute stage after cerebralhemorrhage and the magnitude might reflect the severity of the event, IGF - 1 might be capable of crossing the blood - brain barrier after cerebralhemorrhage and providing some protection against nerve injury, this fact might be of potential clinical applicability.
出处
《医学研究杂志》
2007年第3期73-75,共3页
Journal of Medical Research
