小儿全身麻醉前静注长托宁与阿托品对血流动力学和腺体分泌的影响

Influence of Penehyclidine and Atropine on Hemodynamics and Thirstiness as Premedication of General Anesthesia in Pediatric Patients

目的：观察长托宁阿托品术前用药在小儿全身麻醉中对血流动力学和腺体分泌的影响。 方法：40例3～10岁患儿随机分为长托宁组和阿托品组．均行气管内插管全身麻醉。入室后分别静注长托宁0.01mg／kg。阿托品0．01mg／kg．观察并记录各时点的平均动脉压，心率．血氧饱和度、气道分泌物及其不良反应。 结果：术前用药阿托品组心率明显增快，血压升高（P〈0．05）；长托宁组血压，心率改变不明显。长托宁组抑制患儿气遘分泌物情况明显好于阿托品组（P〈0．05）：两组病人不良反应的差异无显著性差异。 结论：和阿托品比较，长托宁是一种更为理想的小儿全身麻醉的术前用药。

Objective： To investigate influence and degree of penehyclidine and atropine on hemodynamics and thirstiness as Premedication of general anesthesia in Pediatric Patients. Methods： Randomized study, 40 pediatric patients of 3-10 year-old for general anesthesia were randomly divided into penehyclidine group （C group） and atropine group （A group）.Penehyclidine（0.01 mg / kg） was injected intravenously in C group （n=20）, while in A group, atropine （0.01ing / kg） was injected （n=20） when in the operation room .The MAP, heart rate, SpO2 ,the air passage＇s secretion and adverse effect was monitored. Results： Atropine increased heart rate and blood pressure significantly, compare to baseline（P〈0.05）, and slightly changed in penehyclidine group. controlling the air passage＇s secretion in C group were better than that in A group .There are no significant differences in adverse effect between two groups. Conclusion： compare to atropine, Penehyclidine is a better Choice of premedication for Pediatric Patients.