补肾毓麟汤对肾虚性生殖功能障碍大鼠生殖激素影响的实验研究

Effect of Bushen Yulin Decoction on Gonad Hormone Level in Rats with Genital Function Disturbance Due to the Kidney Deficiency

目的观察补肾毓麟汤对模型大鼠血清生殖激素水平的影响。方法用雷公藤多苷片造成雌、雄性生殖功能障碍大鼠模型,观察补肾毓麟汤和克罗米芬对雌、雄性大鼠血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)的含量的影响。结果雌性模型大鼠血清FSH、LH、E2含量与正常组比较无显著性差异,而血清T含量高于正常组(P<0.05);补肾毓麟汤、克罗米芬均能降低血清T含量。雄性模型大鼠血清FSH含量与正常组比较无显著性差异,LH、E2含量高于正常(P<0.05,P<0.01),T含量低于正常组(P<0.01);补肾毓麟汤能降低血清LH、E2含量,升高血清T含量;克罗米芬能降低血清LH含量,但对E2、T含量无明显影响。结论雌、雄性模型大鼠血清生殖激素水平有不同程度改变,补肾毓麟汤能调整紊乱的生殖激素水平,疗效优于克罗米芬。

Objective： To observe the effect of Bushen Yulin decoction on serum gonad hormone level in rats with generative function disturbance Methods： Female and male rat infertility disease model was established by glucodidorm triperygii totorum. The effect of Bushen Yulin decoction and Clomiphene was evaluated by serum level of FSH, LH, E2 and T. Results： Bushen Yulin decoction and Clomiphene could decrease the serum level of T in female model group. Bushen Yulin decoction could decrease the serum level of LH and E2 and increase the serum level of T in male model group. Clomiphene had no significant effect on the serum level of E2 and T, and only decreased the serum level of LH in male model group. Conclusion： There are different change on serum gonad hormone in model group. Bushen Yulin decoction can adjust serum gonad hormone level to normal level. Bushen Yulin decoction has a prominent effect on serum gonad hormone in female and male rat compared with Clomiphen.