医用聚乙二醇小檗碱液预防腰椎管术后硬膜外粘连的临床观察

Clinical Observation on Prevention of Epidural Adhesion of Spinal Canal after operation with Ethylene Phyllodendron Amurense Alkaline (EPAA)

目的 观察医用聚乙二醇小檗碱液（粘连平）预防腰椎管术后硬膜外粘连的临床效果。方法 2004—09-2006—06，采用脊神经后支阻滞麻醉小切口腰椎板开窗减压、椎间盘髓核摘除术治疗536例腰椎间盘突出症患者，473例缝合骶棘肌前在椎板间缺损区域置入粘连平3．0mL。结果 术后2周，无局部及全身不良反应，体温在正常范围内，伤口均Ⅰ期愈合，复查血常规及肝肾功能均在正常值范围；术后6个月：优378例，良76例，进步19例，优良率达95．98％。CT复查显示：放置粘连平者无硬膜外瘢痕粘连；对照组有不同程度的硬膜外瘢痕粘连。结论 粘连平组织相容性好、无毒，能有效预防硬膜外瘢痕粘连，具有临床应用价值。

Objective To observe the clinical effect of preventive epidural adhesion of spinal canal after operation with EPAA. Methods 536 cases of lumbar intercalated disc protruding from September 2004 to June 2006 were depressed and adopted resection of nuclear with blockage of posterior branch and 3 ml EPAA was placed at defect area in 473 cas- es. Results The clinical manifestation was normal with I stage healing and without side effect after 2 weeks. There were 378 cases excellent, 76 cases better and 19 cases improved with good rate of 95.98%. The CT scan shown that there was no adhesion in therapy group and varied scar adhesion in control group. Conclusion EPAA might have good compatibility, non - toxicity that prevent the adhesion with good clinical value.