肝癌患者血清补体检测的临床意义

Clinical Significance of Examination of Serum Complement in Patients with Liver Cancer

目的研究肝癌患者血清补体水平及其变化的临床意义。方法透射免疫比浊法检测C3、C4,酶法检测CH50在42例肝癌与12例肝硬化患者、38例正常人血清中含量并进行对比,分析肝癌及其不同临床分期和手术前后C3、C4和CH50的变化。结果肝癌患者血清C3水平与正常人无明显差别(P>0.05),C4显著降低(P<0.01),CH50显著增高(P<0.01),以甲胎球蛋白(AFP)阴性的肝癌最为明显,且与AFP无相关性;肝癌不同临床分期补体水平有不同表现;手术后C4明显升高(P<0.05),CH50明显下降(P<0.05),复发时再次升高;肝硬化患者的血清补体含量明显低于正常人(P<0.05)。结论肝癌患者血清补体水平存在明显异常,检测血清C3、C4和CH50对肝癌诊断、鉴别诊断、治疗中的动态观察及预后均有重要意义。

ObJective To investigate the clinical significance of the examination and the change of serum complel aent in patients with liver cancer. Method Ca, C4 and CH50 were measured in 42 patients with liver cancer 12 cases of cirrhosis and 38 normal persons with turbidimetric test and EIA. The changes of complement level in different clinical stages of liver cancer, as well as before and after surgery, were observed and analyzed. Results It showed a different performance in different clinical stages of liver cancer. There was no significant difference in serum C3 level between patients with liver cancer and normal persons（ P 〉 0.05）. C4 decreased （ P 〈 0.01 ） and CH50 increased（ P 〈 0.01 ） significandy in patients with liver cancer, especially in the paitents with negative AFP. They were not related to AFP. After operation,C4 increased（P 〈0.05） and CH50 declined obviously（ P 〈 0.05 ）, but they increased at the moment of recurrence. Serum complement levels in cirrhosis patients were obviously lower than those in nomal persons （ P 〈 0.05）. Conclusions Serum complement is obvious abnormal in liver cancer patients. The examination of serum complement levels is important to the diagnosis, distinguish diagnosis, dynamic observation and prognosis of liver cancer.