无龋和患龋儿童唾液中免疫组分的测定及意义

Study on the immune ingredients of saliva in children with or without caries

目的:探讨龋病与唾液中免疫成分的关系。方法:对130例4～6岁幼儿园儿童的患龋情况以及混合唾液的pH值、总蛋白、SIgA和溶菌酶的含量进行检查测定,并对无龋儿童和患龋儿童唾液成分进行比较。结果:130例儿童中,无龋45例,患龋85例,患龋率65.4%。患龋儿童唾液pH、总蛋白、SIgA和溶菌酶分别是(7.10±0.38)g/L、(1.68±0.40)g/L、(60.21±39.23)μg/ml和(19.33±21.20)μg/ml;无龋儿童唾液pH、总蛋白、SIgA和溶菌酶分别是(7.16±0.41)g/L、(1.46±0.35)g/L、(49.31±28.13)μg/ml和(15.43±13.25)μg/ml。无龋儿童和患龋儿童唾液pH值差异无显著性,患龋儿童唾液总蛋白、SIgA及溶菌酶含量明显高于无龋儿童,两者比较差异有显著性(P<0.05)。结论:唾液总蛋白、SIgA及溶菌酶在龋病发病中可能起重要作用。

Objectlve：To study the relationship between dental caries and immune components in saliva.Methods：The status of eariogenesis,pH value and the concentrations of total protein,SIgA and lysezyme in 130 children with 4-6 year old were inspected and detected respectively.Results：The caries incidence was 65.4%.The pH value and the concentrations of total protein,SIgA and lysezyme were （7.10±0.38）g/L.（1.68±0.40）g/L,（60.21±39.23）μg/ml and （19.33±21.20）μg/ml respectively in saliva in children with caries,and （7.16± 0.41 ）g/L, （ 1.46±0.35 ）g/L, （49.31±28.13） μg/ml and （ 15.43±13.25 ）μg/ml respectively in saliva in children without caries.The concentrations of total protein,SIgA and lysezyme in children with caries were markedly higher than those in children without caries,with significant difference between them （P〈0.05）.Conclusion：The total portein,SIgA and lysozyme of saliva may play an important role in the onset of dental caries.