吡罗昔康用法与病人依从性研究

The usage of piroxicam and patient dependence:A clinical study

目的:探讨吡罗昔康治疗类风湿关节炎的最佳方法。方法:根据半衰期与稳态血药浓度原理,将门诊类风湿性关节炎病人随机分为试验组和对照组各50例。试验组在第一个半衰期剂量加倍;对照组采用常规治疗法。结果:坚持治疗率试验组为85.4%,对照组为57.8%,经四格表资料χ2检验P<0.01。结论:第一个半衰期剂量加倍法可明显提高类风湿关节炎病人的依从性。

Objective：To study the optimal method of pivoxicam in the treatment of reeumatoid arthritis.Methods：The mehtod of of doubhng dosage within the first half-life period was utilzed to shorten the time up to steady state concentration accouding to the principle of the half-life period ond steady state concentration.The outpatients with rheumatoid arthritis in the present syudy were randomly allocated either into the treatment group or the control group,with 50 cases in each group.The treatment group or the control group,with 50 cases in each group.The treatment group was treated with the method of doubling dosage within the first half-life period,but the control group only with conventional therapy.Results：The therapeutic rate of persistence was 85.4% in the treatment group,significantly higher than 57.8% in the control group,with significant difference between them （P〈0.01）.Conclusion：The method of doubling dosage within the first half-life period can obviously improve the dependence in patients with rheumatoid arthritis.