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红细胞生成素与神经保护 被引量:1

Erythropoietin and Neuroprotection
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摘要 红细胞生成素(EPO)的作用不仅限于治疗贫血。研究表明,EPO及其受体在中枢神经系统内有广泛表达,并可能与多种神经保护机制有关。这将在以后为预防和治疗神经元损伤提供一条新的途径。 The effect of Erythropoietin (EPO) is not only restricted to the treatment of anemia. Studies have suggested that EPO and its receptors express widely in the central nervous system, and they may be associated with various neuroprotective mechanisms. They may be associated with various neuroprotective mechanisms. This will provide a new approach for the prophylaxis and treatment of neuronal injury in the future.
出处 《国际脑血管病杂志》 2007年第2期106-109,共4页 International Journal of Cerebrovascular Diseases
关键词 红细胞生成素 神经保护 保护机制 神经元损伤 Erythropoietin Neuroprotection Mechanism
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  • 1Jacobson LO, Goldwasser E, Fried W, et al. Role of the kidney in erythropoiesis. 1957. J Am Soc Nephrol, 2000, 11:589 -591.
  • 2Lappin T. The cellular biology of erythropoietin receptors. Oncologist,2003,8:15 - 18.
  • 3Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl A.cad Sci USA, 2000, 97:10526 - 10531.
  • 4Nagai A, Nakagawa E, Choi HB, et al. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture.J Neuropathol Exp Neurol,2001,60: 386-392.
  • 5Siren AL, Fratelli M, Brines M, et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA, 2001,98: 4044 - 4049.
  • 6Zhang F, Signore AP, Zllou Z, et al. Erythropoietin protects CA1 neurons against global cerebral ischemia in rat: potential signaling mechanisms. J Neurosci Res,2006, 83:1241 -1251.
  • 7Chong ZZ,Kang JQ, Maiese K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation, 2002, 106:2973 - 2979.
  • 8Yatsiv I,Grigoriads N,Simeonidou C,et al.Erythropoietin is neuroprotective,improves functional recovery,and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. FASEB J, 2005,19:1701 - 1703.
  • 9Kaiser K, Texier A, Ferrandiz J, et al. Recombiant human erythropoietin prevents the death of mice dining cerebral malaria. J Infect Dis, 2006, 193:987 -995.
  • 10Li X, Gonias SL, Campona WM. Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury.Glia 2005, 51:254 -265.

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