摘要
对照人参总甙（Ｇｉｎ）观察绞股蓝总甙（Ｇｙｐ）对大鼠心、脑微粒体ＡＴＰ酶活性的影响。结果表明Ｇｙｐ体外显著抑制心、脑Ｎａ＋，Ｋ＋－ＡＴＰ酶，并具浓度依赖性。其ＩＣ５０分别为５８．７９±８．０５，５２．０７±６．２５ｍｇ／Ｌ。提示Ｇｙｐ的强心、中枢抑制作用可能与对Ｎａ＋，Ｋ＋－ＡＴＰ酶的抑制有关。
Theefectsofgypenoside(Gyp)onthemicrosomalNa+,K+-ATPasefromratheartsandbrainswereinvestigatedincomparisonwithginsenoside(Gin).TheresultsshowedthatGypcouldinhibittheenzymeac-tivityrapidlyandreversiblyinvitro.Theinhibitionwasinaconcentration-dependmanner.TheIC50ofGypfortheheartandbrainwas58.79±8.05mg/Land52.07±6.25mg/Lrespectively.KineticanalysisrevealedthatGypwasanincompetitiveinhibitorofATP.TheseresultssuggestthatthepositiveinotropcefectandtheinhibitionofCNSbyGyparerelatedtotheinhibitoryactionofGypontheactiyilyofNa+,K+-ATPasefromheartsorbrains.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1996年第5期299-302,共4页
China Journal of Chinese Materia Medica
关键词
人参总甙
绞股蓝总甙
微粒体
ATP酶
心
脑
ginsenoside
gypenoside
sodium,potasiumadenosinetriphosphatase
microsomes
