番茄红素对阻塞性睡眠呼吸暂停综合征患者CRP NO SOD及血脂的影响

Effect of Lycopene on CRP NO SOD and Blood-fat in Obstruction Sleep Apnea Syndrome

目的:观察阻塞性睡眠呼吸暂停综合征(OSAS)患者血清CRP、NO、SOD及血脂的变化,探讨番茄红素对OSAS患者发生心脑血管意外的预防作用。方法:对受试者OSAS组(n=43)和正常对照组(n=30)进行番茄红素干预治疗,测定治疗前后CRP、NO、SOD及血脂的变化。结果:治疗前OSAS组CRP高于对照组(P<0.01),NO、SOD值低于对照组(P<0.05);治疗后OSAS组CRP第4周开始下降,第6周、10周与治疗前比较明显降低(P<0.05),NO、SOD第4w已明显升高(P<0.05),并维持在这一较高水平,2组TC、TG、TC/HDL-C轻度降低(P>0.05)。结论:番茄红素可以降低OSAS患者血清CRP含量,提高血清NO含量和SOD活性,可能对预防OSAS患者发生心脑血管意外有一定作用。

Objective： To investigate the effects of lycopene on cordis and cerebral accidents in obstruction sleep apnea syndrome （ OSAS ） by observing the changes of CRP, NO, SOD and Blood-fat in OSAS. Methods： Subjects, including the OSAS group （ n=43 ） and the control group （n=30）, were all treated with lycopene, then the content of CRP, NO and the activity of SOD were determined before and after treatment. Results： Before treatment, the content of CRP in OSAS group was higher than that in control group （ P〈0.01 ）, the content of NO and the activity of SOD in OSAS group were lower compared with control group （P〈0.05 ）; After treatment, the content of CRP in OSAS group was decreasing at fourth week, and decreased markedly at sixth and tenth week compared to that of before treatment, the content of NO and the activity of SOD in OSAS group had increased markedly at fourth week and maintained at this level at sixth and tenth week （P〈0.05）, the content of TC, TG and the relative value of TC/HDL-C decreased slightly （P〉0.05 ） .Conclusion： Lycopene can decrease the content of CRP, increase the content of NO and the activity of SOD, may have some protection on cordis and cerebral accidents in OSAS.