东乡族原发性高血压血管紧张素转换酶基因多态性

Relationship between angiotensin-converting enzyme I/D polymorphisms and blood lipids in Dongxiang minority with essential hypertension

目的研究血管紧张紊转化酶基因(ACE)单核苷酸多态性(SNP)与东乡族原发性高血压血脂的关系。方法120例原发性高血压患者及102例正常人,用PCR及电泳分析法进行基因分型;分析各基因型与东乡族人群原发性高血压血脂水平的相关性。结果在东乡族高血压患者中,ACE I/D基因携带D等位基因患者的收缩压水平及高密度脂蛋白水平与II基因型有显著差异,其中DD基因型者24个,ID基因型74个,II基因型22个。收缩压水平分别为19．3±11、19．3±12、18．0±10 kPa,P=0．012,高密度脂蛋白水平分别为1．14±0．2、1．3±0．35、1．9±1．11mmol/L,P=0．010,而在正常对照组中则无此差异。结论ACEI/D基因多态性D等位基因与东乡族原发性高血压的高收缩压及较低水平的高密度脂蛋白相关。

Objective To study the relationship between angiotensin-converting enzyme （ACE） I/D polymorphism and blood lipids in Dongxiang minority with essential hypertension. Methods 120 essential hypertension （EH） cases and 102 healthy controls were studied. Genotype of ACE I/D was conducted with PCR and agarose gel electrophoretic analysis. All statistical analyses were performed with SPSS for Windows. Results Association between genotype SBP and HDL in Dongxiang minority with essential hypertension but not in controls was found （P =0.012, 0.010, respectively）, Conclusions D alleles related to SBP, HDL in Dongxiang minority with essential hypertension.