对甲苯磺酸铜催化合成对羟基苯甲酸乙酯的研究

Study on the Catalytic Synthesis of Ethyl p-Hydroxybenzoate by Copper p-Toluene Sulfonate

研究了以对羟基苯甲酸、乙醇为原料、对甲苯磺酸铜为催化剂、合成对羟基苯甲酸乙酯,并讨论了催化酯化的影响因素。实验结果表明,对甲苯磺酸铜是合成对羟基苯甲酸乙酯的良好催化剂,优化的反应条件为:对羟基苯甲酸用量为0.10mol,醇酸摩尔比为4∶1,甲苯磺酸铜用量为2.2g,回流温度下反应4.0h,在此实验下酯化率可达94.3%。产品经傅立叶红外光谱仪及熔点仪表征,证实与目标产物完全一致。

The preparation of ethyl p-hydroxybenzoate by the catalytic reaction of p-hydroxybenzoic acid with ethanol with copper p-toluene sulfonate as catalyst had been studied.The effect of different factors such as the mole ratio of alcohol to acid,the dosage of catalyst,reaction time on the yield of ethyl p-hydroxybenzoate were investigated.The results showed that the optimized reaction conditions were as follows： when the amount of p-hydroxybenzoic acid was 0.10mol,the molar ratio of ethanol to the acid was 4：l,the amount of catalyst was 2.2g, and reaction time was 4.0h at reflux temperature, the esterification yield reached to 94.3%.The product was characterized by FF-IR spectrum and melting point determination. Product was consistent with the target product.