左氧氟沙星在治疗耐多药肺结核的作用分析

Analysis of the treatment effect on multi-drug resistant pulmonary tuberculosis with Levofloxacin

目的观察和评估左氧氟沙星合用其他抗痨方案在耐药肺结核(MDR-PTB)治疗中的疗效。方法将240例MDR-PTB病人随机分配至含左氧治疗组及不使用左氧对照组。治疗组方案为左氧为主联合利福喷丁、力克肺疾、吡嗪酰胺、丁胺卡那,对照组用利福喷丁、力克肺疾、吡嗪酰胺、丁胺卡那,疗程为20个月。结果226例病人完成疗程。治疗组120例,痰菌阴转103例(86%);对照组120例,痰菌阴转59例(49%);治疗组明显高于对照组,治疗组病灶吸收明显,空洞闭合均优于对照组。结论含左氧联合抗痨治疗MDR-TB效果明显。

Objective To observe and evaluate the value-added effect on multi-drug resistant tuberculosis （MDR-PTB） with complex treatment plan （levofloxacin combined with other antitubercular medicines）. Method 240 cases with MDR-PTB were allocated randomly into the treatment group （ with levofloxacin treatment） and the control group （ without levofloxacin treatment）. The treatment group plan used levofloxacin plus rifapentin, isoniasid aminosalicylate, pyrazinamide and amikacin sulfate. The control group was given isoniazid aminosalicylate, pyrazinamide and amikacin sulfate. The treatment period of both groups was 20 months. Results 226 cases completed the treatment course. The sputum smear negative conversion rate of the treatment group was significant better than that in the control group. The figure of the treatment group was 86% （ 103 cases out of total 120 cases）. In contrast, this rate was 49% in the control group （59 cases out of total 120 cases）. The market absorption condition and closure rate in the treatment group were also better than those in the control group. Conclusion There is obviously positive treatment effect on multi - drug resistant pulmonary tuberculosis （MDR-PTB） with levofloxacin.