压电生物传感器检测肝癌细胞的粘弹性

Research on Hepatoma Cell Viscoelasticity by Piezoelectric Sensor

以HepG2肝癌细胞为研究对象,用压电生物传感器研究了肝癌细胞的粘弹性以及紫杉醇对其粘弹性的影响。实验结果表明:HepG2细胞在传感器表面的粘附过程中,细胞粘弹性增加;紫杉醇与HepG2细胞相互作用过程中,细胞粘弹性呈浓度依赖性下降。这一结果与压电传感器的声阻抗响应理论分析一致。

Using piezoelectric biosensor ,the changes and the paclitaxel impacts of HepG2 hepatoma cell viscoelasticity were researched. The results indicated, in HepG2 hepatoma cell adhesion, cell viscoelasticity was increased, during the procession of interactions of HepG2 cell and paclitaxel, cell viscoelasticity was reduced dependent on paclitaxel concentration . That were consistent with the analysis of piezoelectric sensor acoustic impedance theory.