脉炎消注射液治疗周围血管病的临床疗效观察

Clinical Observation on Therapeutic Effect of Maiyanxiao Injection in Peripheral Vascular Diseases

脉炎消注射液是我们研制的纯中药制剂，具有清热解毒、活血化瘀功效，毒理试验结果表明无毒性而安全；药效学研究结果表明具有抗炎、抑菌和良好的免疫抑制作用，抗凝、抑制血小板聚集等功能，临床上用于治疗具有毒热血瘀证或血瘀证的免疫性血管炎及周围血管病病人，收到了较好疗效。本文通过对２７０例住院病人的疗效观察，其中多发性大动脉炎患者１５１例、血栓闭塞性脉管炎Ⅰ、Ⅱ期病人１４例、血栓性静脉炎１８例、肢体动脉硬化闭塞症１３例、糖尿病性末梢神经炎３０例、变态反应性血管炎１２例、ＳＬＥ皮肤血管炎１０例、ＰＳＳ６例、白塞氏病７例、雷诺氏病９例，其有效率分别是９７．３４％、９２．１６％、８３．８３％、９２．３１％、８６．６０％、１００％、９０．００％、８３．８３％、８５．７４％，１００％。并对血压、脉搏、间歇跛行距离（ｍ）、肢体肿胀周径（ｃｍ）、动脉血管内径测定（彩超）等项指标作了治疗前后的比较，结果差异显著，从而证明，脉炎消注射液有抑制自身免疫反应、抗炎、扩张血管、促进血液循环、改善脏器缺血症状、调正血管神经障碍等作用，是目前治疗免疫性血管炎及周围血管病的较好中药制剂。

Maiyanxiao Injection is a herbal preparation prepared in this hospital with effects of Clearing Heat and Detoxicating,Activating Blcod Circulation and Dispersing Stasis.Toxicologic tests showed nontoxic and safe;and pharmaco dynamic studies revealed anti-inflammatory, bacteriostatic and favorable immunoinhibitive actions with anticoagulation and anti-platelet-agglutination. Therapeutic results were observed in 151 cases of polyarteritis with an effective rate of 97.34%,14 patients with thromboangitis obliterans at StagesⅠ& Ⅱ(effective rate 92.16%),thrombotic phlebitis 18 cases(83.63% effective)and in 13 eases of arteriosclerotic occlusion of limbs (92.31%), diabetic peripheral neuritis 30 cases(86.60%),12 cases of alleragic vasculitis (100%), 10 cases of SLE dermal rasculitis (90%), 6 cases of PSS (83.83%),7 cases of Bacet's disease (85.74%) and in 9 cases of Raynaud's disease (effective rate 100%). Comparisons were made before and after treatment on parameters of BP,P,intermittent claudication distance (M),limb swelling circumferences(cm), inner diameter of artery by color ultrasound,revealing significant differences.It was suggested that Maiyanxiao Injection was effective in inhibiting autoimmune reaction,antiinflammation, vasodilatation, promoting blood circulation, improving viscus ischemia and regulating neurovascular disturbances, hence a good herbal preparation in the treatment of immune vasculitis and peripheral vascular diseases.