应用紫杉醇为主方案治疗晚期胃癌疗效观察

Observation on Therapeutic Effects of Paclitaxel Combined with Chemotherapy in Treatment of Advanced Gastric Cancer

目的：观察国产紫杉醇（PTX）联合5-氟脲嘧啶（5-FU）、羟基喜树碱（HCPT）、顺铂（DDP）方案治疗晚期胃癌的疗效和毒副反应。方法：采用PTX135mg／m^2，加入生理盐水静滴3h，第1d；5-FU300mg／m^2，静滴，第1d～第5d；HCPT8mg／m^2，静滴，第1d～第5d；DDP20mg／m^2，静滴，第1d～第5d；3周～4周为1个周期，行2周期治疗后判定疗效。结果：35例可评价疗效，全组无完全缓解（CR）者，部分缓解（PR）15例（42．9％），稳定（NC）13例（37．1％），进展（PD）5例（14．2％），有效率（CR＋PR）42．9％。毒副反应主要为骨髓抑制、脱发和关节肌肉痛，其他毒副反应均较轻微可耐受，无化疗相关死亡。结论：紫杉醇为主方案治疗晚期胃癌疗效肯定，毒副反应能耐受，值得在临床使用。

Objective： To evaluate the effects and the toxicity of the home-made Paclitaxel（PTX） combined with 5-fluorouracil （5-Fu） , hydroxycamptothecin（HCPT）, cisplatin （DDP） in treatment of patients with advanced gastric Cancer. Methods：A total of 38 patients with advanced gastric cancer were cured with PTX 135mg/m^2, 3-hour intravenous infusion on the first day, and 5-FU 300mg/m^2, HCPT 8mg/m^2 and DDP 20mg/m^2 by intravenous infusion on the first day to fifth day. Three or four weeks were as one cycle, and the results were evaluated after 2 periods of treatment. Results： Thirty-five patients could be evaluated. All of them were incomplete response, fifteen cases were in partial response （42.9 % ）, thirteen cases were stable（37.1% ）and 5 cases were in progress（14.2 % ）. Total efficiency rate was 42.9 %. The main toxicities were myelosupression, alopecia, arthralgia. And other side effects were mild. There was no treatment-related death. Conclusion：Therapeutic effects of Paclitaxel combined with chemotherapy in treatment of advanced gastric cancer are affirmation and its toxicity can be tolerated. It is worth using in clinic.