糖糠平降糖机制研究

Study on the Hypoglycemic Mechanism of Tangkangping

目的:研究糖糠平的降糖机制。方法:观察糖糠平(YG-1)对四氧嘧啶糖尿病模型小鼠血糖、甘油三酯降低的影响;对蔗糖负荷四氧嘧啶糖尿病模型小鼠血糖升高的影响;对ip葡萄糖负荷大鼠胰岛素释放的影响。结果:YG-1对四氧嘧啶糖尿病小鼠血糖、甘油三酯有显著降低作用(P<0.05);对蔗糖负荷四氧嘧啶糖尿病小鼠血糖升高有显著抑制作用(P<0.05);对ip葡萄糖负荷大鼠胰岛素释放有显著增加作用(P<0.05)。结论:YG-1的降糖机制可能为类胰岛素作用,以及改变了靶细胞对内原性胰岛素敏感性的增强。

OBJECTIVE： To study the hypoglycemic mechanism of Tangkangping （YG- 1）. METHODS： 1.Observe the effect of YG - 1 on Alloxan induced experimental hyperglycemic mice. 2. Observe its effect on the hyperglycemia of saccharose induced Alloxan hyperglycemic mice .3. Observe its effect on rats insulin releasing of glucose （i. p） induced hyperglycemic rats. RESULTS： 1 .YG- 1 can obviously reduce the blood sugar and triglyceride of Alloxan induced hyperglycemic mice（P〈0.05）. 2.YG- 1 can obviously inhibit the rising blood sugar of saccharose induced Alloxan hyperglycemic mice（P〈0.05） .3.YG- 1 can obviously increase the insulin releasing amount of glucose induced hyperglycemic rats（P〈0.05）. CONCLUSION：The hypoglycemic mechanism of YG- 1 may be the increasing of endogenous insulin by the effect of insulin and target cell membrane changing.