伤疡愈凝胶的制备及质量标准研究

Study on Preparation and Quality Standard of Shangyangyu Gel

目的:制备伤疡愈凝胶并建立其质量标准。方法:以卡波姆940为凝胶基质制备伤疡愈凝胶。采用分光光度法在516nm波长处测定其含量;其它成分用薄层色谱法进行鉴别。结果:左旋紫草素浓度在8.048～40.24μg.mL-1范围内线性关系良好(r=0.9998),平均回收率为99.45%(RSD=1.13%)。结论:本制剂制备工艺简便,所建标准可用于质量控制。

OBJECTIVE： To prepare Shangyangyu gel and establish a standard for its quality.METHODS： Shangyangyu gel was prepared using carbamer 940 as matrix. Its content was identified by spectrophotography, with the wavelength set at 516nm, and its other compositions were determined by TLC. RESULTS： The concentration of L- shikonin had good linear correlation with absorbance in the range of 8.048-40.24μg·mL^-1（r = 0.999 8） . The average recovery rate was 99.45% （RSD = 1.13%） . CONCLUSION： This method for preparation of Shangyangyu gel was simple in technique and the standard can be used for the quality control.