山莨菪碱缩短产程的临床研究

Clinical study on promoting the stage of the multigravidae by using of anisodamine

目的探讨山莨菪碱(654-2)在促进产程中的作用。方法选取2004年9月至2006年10月期间入住我院初产妇,随机分为山莨菪碱治疗组150例,安定治疗组150例,对照组100例。山莨菪碱组给予静脉推注654-210mg,安定组给予静脉推注安定10mg,对照组不推注任何药物。结果第二产程山莨菪碱组低于安定组(P<0.05),剖宫产率654-2组与安定组间P>0.05,差异无显著性,654-2组与对照组、安定组与对照组间剖宫产率差异具有显著性;产后出血率、新生儿窒息率654-2组和安定组与对照组间P均大于0.05,差异无显著性。结论应用654-2可达到与安定一样的促进第一产程进展的作用,对第二产程也有促进作用,且不增加新生儿窒息率和产后出血率,是一种安全有效的促进产程进展的方法。

Objective To explore the clinical effect by using of anisodamime （654-2） to muhigravidaes. Methods Among 150 muhinravidaes deliveryinn, 150 were treated with 654-2, the other 150 muhinravidaes were treated with diazepam. And 100 muhinravidaes were not given any medineie for control. Results The in-st and second stage of the muhiusirm of 654-2 and diazepam are all shorter than the control group. And the in-st stage of 654-2 group has no signifinant difference with the diazepam group. But the second stage of rite mul- tiusinn of 654-2 shorter than the dizapam. The rate of operative delivery in the 654-2 group and diazepam group were lower than the control, h was significantly different between the 654-2 group and diazepam group the rate of operative delivery has no different（P〈0.05）. And the rate of postpartum hemorrhage and neonatal asphyxia were not significantly different in the three groups （P〉0.05）. Conclusion 654-2 has the like clinical effect as diazepam for muhigravidaes. And h can also promote the second stage too. It is safety by using 654-2 to muhigxavidaes with lower rate of operative deliver but not increase the rate of postpartum hemorrhage and neonatal asphyxia.