对氯苯乙酮肟醚衍生物的合成及生物活性

Synthesis and Bioactivity of 4-Chlorophenyl Methyl Ketone Oxime Ether Derivatives

为寻找高活性的新农药化合物,通过2-取代氨基-1-对氯苯乙酮-1-肟与卤代烃反应,设计并合成了35个对氯苯乙酮肟醚衍生物,其结构均经核磁共振氢谱和元素分析确证。初步的生物活性测定结果表明,该类化合物具有一定的杀虫、抑菌及除草活性,其中C9、C12在500mg/L时对蚜虫Aphis craccivaora的致死率达到100%;C10、C12、C15和C23在1000mg/L时对朱砂叶螨Tetranychus cinabarinus的致死率达到100%;C29、C30和C31在500mg/L时对黄瓜白粉病菌Sphaerotheca fuligineas的抑制率达到95%以上;C29、C30、C33和C35在100mg/L时对马唐Digitaria sanguinalis的抑制率达到90%以上。

In search of novel pesticide leading compound with high bioactivity, thirty-five 4-chlorophenyl methyl ketone oxime ether derivatives were designed and synthesized by the reaction of 2- substituted amino 4-chlorophenyl methyl ketone oxime with halohydrocarbon. The structure of all novel compounds was confirmed by I H NMR and elemental analysis. Preliminary bioassays showed that some compounds exhibited certain insecticidal and herbicidal activities. The mortality of C9, C12 to Aphis craccivaora reached 100% at the concentration of 500 mg/L. The mortality of C10, C12, C15 and C23 to Tetranychus cinabarinus reached 100% at 1 000 mg/L. The inhibition rate of C29, C30 and Ca31 to Sphaerotheca fuligineas was over 95 % at the concentration of 500 mg/L. The inhibition rate of C29, C30 ,C33 and C35 to Digitaria sanguinalis was over 90% at the concentration of 100 mg/L.