哈伯因对抑郁症认知功能和生活质量的影响

Effects of huperzine on cognition function and life quality of patients with depression

目的探讨哈伯因对抑郁症认知功能、生活质量的影响。方法患者组:100例抑郁症患者随机分为两组,研究组(哈伯因合并氟西汀治疗)和治疗组(单用氟西汀治疗)共治疗6周。分别于治疗前和治疗第6周末采用汉密尔顿抑郁量表(24项,HAMD)、威斯康星卡片分类测验(WCST)、世界卫生组织编制的生活质量综合评定问卷(WHO.QOL-100)评定患者的抑郁症状、认知功能和生活质量。对照组:100例健康志愿者,评定其认知功能和生活质量。结果抑郁症患者组WCST的总测验次数、持续错误数、随机错误数分值高于对照组,正确次数、完成分类数及WHO.QOL-100各因子分值低于对照组,差异有统计学意义(P<0.01)。研究组治疗后WCST的总测验次数、持续错误数、随机错误数分值均下降,正确次数、完成分类数及WHO.QOL-100分值提高,与治疗前及治疗组治疗后比较差异有统计学意义(P<0.01)。结论抑郁症存在认知功能损害和生活质量降低。哈伯因能有效改善抑郁症认知功能,从而提高生活质量。

Objective To study the efficacy of huperzine on cognition function and life quality in depression. Methods The patient group including 100 patients with depression was randomly assigned to two groups： one is the study group （50 cases） treated with huperzine and fluoxetine simultaneously , the other is the treatment group（50 cases） treated with only fluoxetine for 6-weeks. Hamilton Depression Rating Scale（ HAMD）, Wisconsin Card Sorting Test （WCST） and General Quality of Life Inventory of WHO （WHO. QOL-100） were assessed for depressive symptoms, cognitive function and the quality of life before and after 6 weeks. The control group （50 cases） was healthy volunteers without somatic diseases and mental disorders. Results The patient group was worse than the control group in WCST and life quality （P〈0.01）. The treatment caused significant changes of WCST and WHO. QOL-100 in the study group （P〈0. 01）. After treatment the study group was significantly better than the control group in WCST and WHO. QOL-100 of （P〈0.01）. Conclusion Depression has cognitive impairments and low life quality. Huperzine can improve significantly cognitive function and life quality of depression patient.