丙戊酸钠治疗精神病患者的攻击行为

Sodium valproate in treatment of aggression of psychiatric patients

目的了解丙戊酸钠对精神病患者冲动攻击行为的临床效果。方法将36名具攻击行为的住院精神病患者随机分为两组,在原用药物不变情况下,分别加用含丙戊酸钠或不含丙戊酸钠的胶囊治疗,用修订的外显攻击量表(MOAS)和BPRS定期作盲式评定。结果研究组控制冲动攻击行为的有效率为63.2%,明显比对照组23.5%高(P<0.01),未出现明显药物不良反应。结论对具有攻击行为的精神病患者,可加用丙戊酸钠来降低患者的激怒和冲动行为。

Objective To investigate the effect of sodium valproate on aggression in psychiatric patients. Methods Using double-blind control method, 36 psychiatric patients with aggression were enrolled. The examples were divided into the two groups randomly,sodium valproate combining anti-psychiatrics group （group A） and placebo combining anti-psychiatrics group（group B）. To assess the efficience by Modified Overt Aggression Scale and Brief Psychiatric Rating Scale. Results The effective rates was 63.2% in group A and 23.5% in group B respectively. There was a siginficant difference between the two groups （P〈0.01）. Sodium valproate had less side-effects. Conclusion Sodium valproate combining anti-psychiatrics is effective and safe choice for the treatment of aggression in psychiatric patients.