TGF-β1测定在2型糖尿病肾病早期诊断中的应用价值

Value of detection of TGF-β1 in early diagnosis of nephropathy due to type 2 diabetes

目的探讨尿微量白蛋白(UmALB)、血清转化生长因子(TGF-β1)的定量检测在糖尿病肾病早期诊断中的临床应用价值。方法根据尿蛋白定性试验,把85例2型糖尿病患者分为尿蛋白阴性、尿蛋白±～+、尿蛋白++及尿蛋白+++以上共4组,采用免疫散射比浊法测定UmALB,ELISA法测定TGF-β1含量,并与正常对照组比较。结果糖尿病患者尿蛋白阴性组UmALB、TGF-β1均高于正常对照组;2项指标检测结果随着尿蛋白阳性程度的增加而升高,比较呈显著差异。高于正常参考值上限的检出率,TGF-β1指标高于UmALB指标。结论UmALB、TGF-β1均可作为糖尿病肾病早期诊断的指标,TGF-β1比UmALB更为敏感。

Objective To assess the value of determination of urine micro- albumin （UmALB）, sertun transforming growth factor beta 1 in early diagnosis of diabetic nephropathy. Methods Eighty - five type 2 diabetic patients were divided into 4 groups and the levels of negative urine protein, positive urine protein （ urine protein ± - ＋ ＋ ＋ ）. UmALB was measured by immunonephelometry, TGF - β1 was measured by ELISA, and the data were compared with that of control group. Results UmALB and TGF - β1 of DM patients were higher than that of normal control with negative results of qualitative tests of urine protein. The levels of 2 index elevated with the increase of positive urine protein. Conclusion UmALB and TGF - β1 could be used as sensitive index for early diagnosis of diabetic nephropathy, TGF - β1 is more sensitive than UmALB.