曲美他嗪、螺内酯联合治疗充血性心力衰竭的临床观察

Clinical observation on the effect of Trimetazidine Dihydrochloride and Spironolactone on congestive heart failure

目的探讨曲美他嗪、螺内酯联合治疗充血性心力衰竭的临床效果。方法收集2002年5月～2006年8月住院的充血性心力衰竭患者64例,将其随机分为治疗组(n=32)和对照组(n=32),治疗组在对照组常规治疗(阿司匹林、血管紧张素转换酶抑制剂ACEI、β受体阻滞剂、速尿、正性肌力药及他汀类药物治疗)基础上加用曲美他嗪(20mg,每日3次口服)和螺内酯(每次20mg,每日3次口服)。结果治疗组显效16(50.0%),有效13例(40.6%),总有效率90.6%;对照组显效12例(37.5%),有效11例(34.4%),总有效率71.9%,两组总有效率(P<0.05)显示差异有显著性。结论曲美他嗪和螺内酯联合用于充血性心力衰竭的治疗效果好,值得在临床推广使用。

Objective To discuss the effects of Trimetazidine Dihydroehloride and Spironolactone on congestive heart failure. Methods There 64 congestive heart failure patients were randomly divided into the observation group and control group each consisted of 32 cases. The control group was treated with Aspirin, β- blockers, ACEI, Lasix, and inotropic drug and Statins. The patients in observation group were treated with the same drugs plus Trimetazidine Dihydrochloride （20mg, 3 times per day, P. O） and Spironolactone（20mg,3 times per day, P.O）. The results were analyzed. Results Marked effective rate and effective rate in observation group were 50% （16/32） and 40.6% （13/32） with a total effective rate of 90.6% . While that in the control group were 37.5% （12/32） and 34.4% （11/32）, with a total effective rate of 71.9%, showing significant differences between the two groups （P 〈 0.05）. Conclusion Trimetazidine Dihydrochloride and Spironolactone are effective for treatment of patients with congestive heart failure.