冠心病患者血清超敏C反应蛋白的水平和意义

The level and significance of serum hugh C-reactive protein in patients with coronary heart disease

目的通过测定血清超敏C反应(hs-CRP)蛋白的浓度,探讨超敏C反应蛋白与冠心病严重程度关系。方法采用胶乳增强免疫透射比浊法测定48例稳定型心绞痛(SAP)患者,58例不稳定型心绞痛(UAP)患者,39例急性心肌梗死(AMI)患者和165例健康人血清超敏C反应蛋白浓度,并进行比较。结果SAP、UAP、AMI患者血清的超敏C反应蛋白浓度均明显高于健康人的浓度。根据冠状动脉病变程度采用随机方差分析,超敏C反应蛋白平均浓度在正常对照组、SAP组、UAP组、AMI组依次增高,两两比较均存在显著性差异,与冠脉病变程度呈正相关。结论冠心病患者血清中超敏C反应蛋白浓度比正常人血清浓度明显升高,C反应蛋白水平高低可反映冠心病患者病变的程度。

Objective To explore the relationship between high - sensitivity C - reactive protein and coronary heart disease. Methods High - sensitivity C - reactive protein（ hs - CRP） levels in serial serum samples from 48 stable angina patients （SAP）, 58 unstable angina patients （UAP）,39 impatient cardiac infarction patients（AMI） and 165 heath parson were determined by particle-enhanced c assay. Results Hs - CRP levels of stable angina patients, unstable angina patients and impatient cardiac infarction patients were obviously higher than that of heath parsons. Based on result of completely randomized variance analy- sis , Hs - CRP levels was increased successively from heath parsons to stable angina patients, unstable angina patients and impatient cardiac infarction patients, showing significant difference. It was positive correlated to coronary condition. Conclusion Hs- CRP levels of inpatients with coronary heart disease is higher than that of heath person. The levels of high - sensitivity C - reactive protein reflect the condition of coronary heart disease.