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人类NRAMP1基因与结核分枝杆菌的易感性 被引量：3

Human NRAMPI gene and its susceptibility to Mycoplasma tuberculosus
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摘要 20多年前在对小鼠的疾病易感性研究中发现,有一基因对疾病的易感性起决定性的作用,近年来研究发现NRAMP1(Natural-resistance-associtted macrophage protein1,自然抵抗相关巨噬细胞蛋白1)是主要的侯选基因,NRAMP1的结构显示具有膜转运蛋白的典型特征,它存在于吞噬小体膜上,它的主要功能是通过改变含有微生物的吞噬体液泡内环境来控制其复制,从而消灭胞内菌.国外已做了大量研究证实NRAMP1基因与麻风病、结核病的感染有明显的关联,国内也已对汉族人NRAMPI基因进行了研究,同样证实NRAMP1基因的某些位点的多态性与结核的发病相关,黎族是中国55个少数民族中唯一分布在海南省的少数民族,据调查显示黎族人痰涂片检出率高于同期汉族人的9.9%[25]的平均水平,除了结核病的发生与环境因素有关外,是否也与NRAMP1基因某些位点的多态性有关呢?值得我们研究。
作者 林容 林峰
机构地区 海南医学院附属医院
出处 《中国热带医学》 CAS 2007年第4期615-616,622,共3页 China Tropical Medicine
关键词 NRAMP1基因 结核病 多态现象 疾病易感性
分类号 R52 [医药卫生—内科学]
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参考文献25

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共引文献40

同被引文献59

  • 1安雅臣,冯福民,袁聚祥,纪春梅,王育华,郭梅,邓小娟,高宝霞,王东,刘茜.NRAMP1基因INT4和3’UTR位点多态性与肺结核易感性的研究[J].中华流行病学杂志,2006,27(1):37-40. 被引量：19
  • 2游小燕,刘益平,朱庆.鸡NRAMP1基因抗沙门氏菌的研究进展[J].安徽农业科学,2006,34(19):4949-4950. 被引量：3
  • 3应三成,张义正.藏猪NRAMP1基因的定量表达研究[J].四川大学学报（自然科学版）,2007,44(3):697-701. 被引量：8
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引证文献3

二级引证文献3

中国热带医学
2007年 第4期

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