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自膨式带膜支架并导管灌注化疗对食管恶性狭窄的治疗效果

APPLICATION OF SELF-EXPANDABLE AND COVERED STENTS COMBINED WITH TRANSCATHETER-INFUSION CHEMOTHERAPY IN THE TREATMENT OF MALIGNANT ESOPHAGEAL STENOSIS
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摘要 目的探讨自膨式带膜支架置入结合导管灌注治疗食管恶性狭窄的临床应用效果。方法将64例食管恶性狭窄病人随机分为两组,每组32例。对照组仅置入自膨式带膜支架,导管灌注组在置入自膨式带膜支架同时行导管灌注化疗。结果两组各32个支架一次性成功置入,置入支架后,吞咽困难100%得到缓解。没有发生与置入术有关的严重并发症。随访观察,置入自膨式带膜支架生存达1年的病例,导管灌注组明显多于对照组(χ2=3.87,P<0.05)。导管灌注组再狭窄率明显低于对照组(χ2=5.89,P<0.05)。结论中晚期食管恶性狭窄置入自膨式带膜支架,能迅速解除吞咽困难,改善病人生存质量,结合导管灌注,能有效防止再狭窄,抑制肿瘤生长,延长病人生存时间。 Objective To investigate the efficacy of self-expandable and covered stents combined with transcatheter-infusion chemotherapy for malignant esophageal stenosis (MES). Methods Sixty-four patients with MES were divided into two groups: control group (32 cases, treated with stenting) and treated group (32 cases, treated with stenting plus transcatbeter-infusion chemotherapy). Results Stents were successfully placed in all 64 the cases. Dysphagia relieved in all the patients after stenting. No severe procedure-related complications were encountered. Follow-up indicated that one-year survival in the treated group was obviously higher than that in the control group (Х^2=3.87 ,P〈0.05), recurrent stenosis markedly lower than that in the control group (Х^2= 5.89,P〈0.05). Conclusion Esophageal stenting is a safe and efficient method relieve obstruction immediately and improve the quality of life of patients with advanced malignant esophageal stenosis, which, combined with transcatbeterinfusion chemotherapy, can effectively prevent recurrent stenosis, inhibit tumor cells growth and prolong the patients' life span.
出处 《齐鲁医学杂志》 2007年第1期60-61,64,共3页 Medical Journal of Qilu
关键词 支架 食管狭窄 导管插入术 药物疗法 stents esophageal stenosis catheterization drug therapy
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