重组干扰素α-2b鼻腔给药治疗反复呼吸道感染效果

EFFECTS OF RECOMBINANT INTERFERON α-2b VIA INTRANASAL MEDICATION FOR CHILDREN WITH REPEATED RESPIRATORY TRACT INFECTION

目的探讨儿童反复呼吸道感染的有效治疗方法。方法85例病儿随机分为治疗组和对照组,两组采用相同的抗感染及对症治疗,治疗组在体温正常3 d后给予重组干扰素α-2b(rIFN-2b)105U/d,双鼻腔内交替滴入,总疗程为15 d。结果治疗组病儿呼吸道感染的频率明显低于对照组(t=4.35,P<0.01),感染后的主要症状轻,感染所持续的时间短于对照组(t=4.05,P<0.01),且无明显副作用。结论rIFN-2b鼻腔内给药治疗反复呼吸道感染有明显效果。

Objective To explore an effective therapy for children with repeated respiratory tract infection. Methods Eighty-five sick children were randomized to control group and treated group. The antibiotics and symptomatic therapy was the same for both groups, the only different was that for the treated group, recombinant interferon α-2b （10S U/d） was given after the temperature returned to normal for three days. The course lasted for 15 days. Results Incidence of repeated respiratory tract infection in the treated group was lower than that in control （t=4.35,P〈0.01）. Symptoms of infection were milder and time lasting shorter （t=4.05,P〈0.01）. No obvious side effects were noted. Conclusion The effect of intranasal medication of interferon α- 2b for children with repeated respiratory tract infection is significant.