食管鳞状细胞癌中MMP-9、CD-147的表达及意义

Expression of Matrix Metalloproteinases-9 and CD-147 in Human Esophageal Squamous Cell Carcinoma

目的:探讨基质金属蛋白酶9(MMP-9)和CD-147在食管鳞状细胞癌的表达及其与肿瘤浸润转移的关系。方法:应用免疫组化S-P法观察57例食管鳞癌组织中MMP-9、CD-147的表达,并探讨其与食管鳞癌临床病理资料的关系。结果:MMP-9、CD-147在癌组织中的阳性表达率分别为82．46%,64．91%;在癌旁组织中的阳性表达率分别是29．82%,8．77%。在食管鳞癌中,MMP-9及CD-147的表达均与食管鳞癌的浸润深度有关,与分化程度无明显关联;有淋巴结转移的病例阳性表达率明显高于无淋巴结转移组。结论:MMP-9及CD-147的表达均与食管鳞癌的浸润深度及淋巴结转移有关。

Objective： To investigate the expression of matrix metalloproteinase-9 （MMP-9） and CD-147 in human esophageal squamous cell carcinoma （ESCC）. Methods： The expression of MMP-9 and CD-147 was detected in 57 patients with ESCC by immunohistochemical S-P method. Results： The expression of MMP-9 and CD-147 had a significant difference between esophageal squamous cell carcinoma and esophageal epithelial cells from normal tissues adjacent to the tumours, and had a significant relevance to infiltrating depth and lymph node metastasis, but no association was observed with pathological grades. Conclusion： Both MMP-9 and CD-147 are all related to infiltrating depth and lymph node metastasis of esophageal squamous cell carcinoma.