FOXP3的研究进展

The research progress of FOXP3

在免疫调节机制中，CD4^＋CD25^＋Treg细胞和FOXP3转录因子成为近十年来的一个研究热点。CD4^＋CD25^＋Treg细胞在免疫调节中的重要作用已经得到了肯定，FOXP3被证实是CD4^＋CD25^＋Treg细胞的发育和功能起关键作用的调节子。目前认为，至少在鼠类，FOXP3是CD4^＋CD25^＋Treg细胞区别于CD4^＋CD25^-T细胞的一个较特异性的标志。影响FOXP3诱导表达的因素很多，FOXP3介导的免疫调节机制也涉及多种分子，对FOXP3的更深入研究有助于发挥其在免疫调节中的重要作用。

CD4^＋CD25^＋Treg cells and transcription factor FOXP3 have been the focus of research in the field of immunoregulation mechanisms in the last ten years . It has been confirmed that CD4^＋CD25^＋Treg cells play a important role in immunoregulation and FOXP3 has emerged as a critical regulator of the develop-ment and function of CD4^＋CD25^＋Treg cells . Recently , it is considered that FOXP3 is a more specific marker to distinguish CD4^＋CD25^＋Treg cells from CD4^＋CD25^- T cells at least in mouse. There are many factors to influence the induction and expression of FOXP3 and many kinds of molecules are involved in immune regulation by FOXP3 , so it is helpful to provide more insight into the role of FOXP3 in immunoregulation.