CD4^＋CD25^＋调节性T细胞的胸腺发育机制

Mechanisms involved in the Thymic Development of CD4^＋CD25^＋ regulatory T cells

天然产生的CD4^＋CD25^＋调节性T细胞（Treg）细胞不仅是机体维持自身耐受的重要组成部分，而且在肿瘤免疫、抗感染免疫、免疫病理、移植物耐受、阻止自身免疫反应和维持机体免疫平衡等方面都具有重要意义。近年来关于发育机制的研究初露端倪，对这些细胞产生的组织定位、相互作用的细胞、参与发育的信号分子等都有较迅速的进展。对上述问题的了解，不仅有利于对Treg细胞本身的研究，同时，对于Treg细胞相关疾病的发病机制和防治研究也具有重要的理论意义和应用前景。

Naturally occurring CD4^＋CD25^＋ Tregs are not only the key component that actively maintain self-tolerance, but also involved in the control of tumor immunity, microbial immunity, immunopathology, transplantation, autoimmunity and immune homeostasis. In the recent years, there has been a substantial advance in our understanding of the mechanism for their development including the site where they are generated, the cells and the signal molecules that are required for their development. The understanding of these mechanisms favors the further progress in Treg biology and pathology and in clinical applications of Tregs to treat and prevent immunological diseases and to control immune responses for the benefit of the host.