葛根素对创伤性休克兔心肌损伤的保护作用

Protective Function of Gegensu on Treating Cardiac Muscle Injury of Rabbits With Traumatic Shock

目的:探讨葛根素对创伤性休克兔心肌损伤的保护作用。方法:日本大耳白兔32只,随机分假手术、休克、复苏和治疗四组,每组8只。制作创伤性休克模型,复苏组和治疗组分别在休克1.5小时后予以平衡液进行复苏、静脉输注葛根素治疗。各组于休克前,休克后0.5、1.5、2、3、4小时采集血液,检测血清肌钙蛋白Ⅰ(cTnI)水平及肌酸激酶(CK)活性。结果:家兔创伤性休克90min后血清cTnI浓度明显升高(P<0.01),休克后180 min复苏组cTnI显著低于休克组(P<0.01),治疗组在休克后120min时cTnI即明显低于复苏组(P<0.01);CK在休克后180min时才出现少许的变化,治疗组与复苏组无明显差异。结论:创伤性休克存在心肌损伤,葛根素对家兔创伤性休克心肌的损伤具有良好的保护作用。

Objective：To explore the protective function of gegensu on treating cardiac muscle injury of rabbits with traumatic shock. Methods：32 Japanese white rabbits were randomly divided into the contrast group, the shock group, the resuscitation group and the treatment group with 8 rabbits in each group. The rabbit models with traumatic shock were established. The resuscitation group was treated by balancing solution and the treatment group by Gegensu after 1. 5 hours＇ shock. Blood samples at 0.5, 1.5, 2, 3 and 4h after shock were collected and the level of cTnI and the activity of CK were detected. Results： The thickness of cTnI after 1.5h＇shock was obviously increased （P 〈 0.01 ）. The thickness of cTnI after 2h＇s shock in the resuscitation group was significantly lower than that in the shock group （P 〈 0.01 ）. The thickness of cTnl after 1.5h＇s shock in the treatment group was lower than that in the resuscitation group （P 〈 0.01 ）. The activity of CK had some variation only after 2h＇ shock. The variation in the treatment group and the resuscitation group had no significant difference. Conclusion：Rabbits with traumatic shock has cardiac muscle injury and gegensu has good effect on treating rabbits with traumatic shock.