摘要
通过比较分别饲喂不同蛋白源(酪蛋白、大豆分离蛋白、Proso m illet醇溶蛋白)饲料的小鼠血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)、甘油三酯(TG)浓度,旨在评价Proso m illet醇溶蛋白对小鼠胆固醇代谢的特定作用,并通过体外实验探讨其作用机理。结果显示,以Prosom illet醇溶蛋白(添加1.83%Lys和0.23%Trp)为唯一氮源的小鼠日粮对TC、TG无明显作用,却能显著提高小鼠血清HDL-c浓度(P<0.05),降低小鼠动脉硬化指数(AI)。但在体外其并不能抑制羟甲基戊二酸单酰辅酶A(HMG-CoA)还原酶的活性,即不能直接抑制胆固醇的合成,所以,其对胆固醇代谢的调节作用另有其他途径。
The objective of this study was to evaluate the effect of proso millet prolamin concentrate (PMP) on cholesterol metabolism in mice, by comparing the concentration of serum total cholesterol ( TC), high - density lipo- protein cholesterol ( HDL - c) , low - density lipoprotein cholesterol ( LDL - c) and triglyceride (TG) of three mice groups given diets respectively containing PMP (supplemented with 1.83% Lys and 0.23% Trp), casein or soy protein isolation (SPI) as protein sources. As the results present, the mice group fed with PMP diet supplemented with Lys and Trp exhibits significantly higher HDL - c concentration ( P 〈 0.05 ) and the lowest atherogenic index (AI) among the three mice groups, without change of levels of TC and TG. In vitro, the PMP can not suppress the activity of 3 - hydroxy -3 - methylglutaryl - coenayme A ( HMG - CoA) reductase, which means PMP can not inhibit directly the synthesis of cholesterol. Maybe, PMP adjusts the metabolism of serum cholesterol by some other ways.
出处
《中国粮油学报》
EI
CAS
CSCD
北大核心
2007年第1期101-104,共4页
Journal of the Chinese Cereals and Oils Association