制何首乌多糖对老年性痴呆模型小鼠的影响

Effect of Radix Polygoni Multiflori Preparata Polycose on Senile Dementia in Rabbit Model

目的:观察制何首乌多糖对老年性痴呆小鼠的作用。方法:应用D-半乳糖复制小鼠老年性痴呆模型,灌胃给服制何首乌多糖溶液,观察其对模型小鼠的作用。结果:制何首乌多糖能够提高模型小鼠学习记忆能力,降低模型小鼠脑内脂褐质含量,降低实验动物脑内单胺氧化酶的含量,提高模型动物海马部位一氧化氮合酶活性,明显提高实验动物的超氧化物歧化酶、过氧化氢酶活力。结论:制何首乌多糖具有抗实验性老年性痴呆作用。

Objective： To observe the effect of radix polygoni multiflori preparata polycose on rabbit of senile dementia. Methods： The rabbit model of senile dementia was established by galactose. The radix polygoni multiflori preparata polycose liquid was intragastic administrated, its effect on rabbit model was observed. Results： In rabbit model of senile dementia, the radix polygonia multiflori preparata polycose could improve the ability of learning and memory, reduce the level of cerebral lipofusin and monoamine oxidase, activate nitricoxide synthase in Ammon＇s horn and superoxide dismutase and catalase.Conclusion： Radix polygoni multiflori preparata polycose has the effect of resistance in experimental senile dementia.