摘要
目的:应用正电子发射计算机断层显像,观察韩氏穴位神经刺激仪(简称HANS仪)刺激百会穴对异丙酚麻醉脑葡萄糖代谢的影响。方法:18只实验用小型猪随机分为3组,HANS组(n=6),基础麻醉后,采用HANS仪电刺激百会穴,以2/100Hz变频电刺激25min,注射显像剂18F-FDG32min后PET扫描;异丙酚组(n=6),基础麻醉后输注异丙酚6mg/kg·h,15min后用1min静注显像剂,继续输注异丙酚6mg/kg·h,32min后PET扫描;针药复合组(n=6),基础麻醉后,HANS仪以2/100Hz变频电刺激百会穴25min,停电针,输注异丙酚6mg/kg·h,15min后用1min静注显像剂,异丙酚6mg/kg·h继续输注32min后PET扫描。结果:HANS仪2/100Hz变频刺激百会穴使异丙酚麻醉相应脑区葡萄糖代谢明显下降(P<0.01)。结论:电刺激百会穴具有加强异丙酚麻醉效应的作用,其作用机制之一是显著降低了脑代谢。
Objective： To investigate the effects of Baihui electroacupuncture by HANS on propofol anesthesia by using positron emission tomography（PET）. Methods： Eighteen pigs were randomly divided into 3 groups： HANS group（n =6） was stimulated by HANS（2/100 Hz） on Baihui for 25 min after anesthesia and then were scanned by PET 32 min after ^18F-FDG was injected; Propofol group（ n = 6） was continuously injected propofol （6 mg/kg, h）. ^18F-FDG was injected 15 min later and then was scanned by PET 32 min after ^18F-FDG was injected; HANS combined propofol group（ n = 6） was stimulated by HANS（2/ 100 Hz） on Baihui for 25 min. After stopping HANS, propofol （6mg/kg · h） was continuously injected. ^18F-FDG was injected 15 minute later and then was scanned by PET 32 min after ^18F-FDG was injected. Results： The cerebral glucose metabolism was greatly decreased after propofol anesthesia combined with Baihui electroacupuncture by HANS. Conclusion： Baihui electroacupuncture by HANS can enhance propofol anesthesia and one of the mechanisms could be the decrease of the cerebral glucose metabolism.
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2007年第1期36-38,共3页
Chinese Journal of Pain Medicine
基金
2003年广东省中医药局资助项目(编号103103)
